This PDF presents Module 5: Implementation of EU Horizon projects, a practical guide for coordinators and partners whose Horizon Europe project has been successfully funded. It covers the full implementation phase, including Grant Agreement preparation, roles and access rights in the EU Funding & Tenders Portal, budget management under actual cost and lump-sum schemes, reporting and payment procedures, amendments, and record-keeping. The module also addresses project governance structures, data management plans, open science requirements, gender equality, ethics, and effective project management tools, supporting beneficiaries in delivering high-quality results in compliance with Horizon Europe rules and Mission-oriented expectations.