This PDF provides an in-depth overview of the Horizon Europe Work Programme 2026–2027 for EU Missions, with a specific focus on the Mission Adaptation to Climate Change. It explains the political and strategic context of the Mission, its objectives, governance approach, and the structure of calls for proposals under HORIZON-MISS-2026-01-CLIMA. The document details priority topics, budgets, expected outcomes and impacts, eligibility conditions, and requirements for demonstration and replication activities, with particular attention to climate adaptation solutions for regions, local authorities and cultural heritage. It serves as a key reference for applicants seeking to align project ideas with Mission priorities and policy-driven expectations.